| Autor: |
Cavalcante-Silva LH; Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil. luiz0710@gmail.com., Falcão MA; Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil. falcao.map@outlook.com., Vieira AC; Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil. carolinavieira2708@gmail.com., Viana MD; Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil. viana.mdm@gmail.com., de Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Posgraduate Program in Pharmaceutical Sciences, Federal University of Alagoas, Maceió 57020-720, Brazil. jotaaraujo2004@gmail.com., Sousa JC; Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, Brazil. jessicacelestino26@hotmail.com., da Silva TM; Molecular Sciences Department, Federal Rural University of Pernambuco, Recife 52171-900, Brazil. taniasarmento@dcm.ufrpe.br., Barbosa-Filho JM; Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, Brazil. jbarbosa@ltf.ufpb.br., Noël F; Laboratory of Biochemical and Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-912, Brazil. fnoel@pharma.ufrj.br., de Miranda GE; Laboratory of Marine Algae, Department of Systematics and Ecology, Federal University of Paraíba, João Pessoa 58051-900, Brazil. mirandag@dse.ufpb.br., Santos BV; Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, João Pessoa 58051-900, Brazil. barbara@ltf.ufpb.br., Alexandre-Moreira MS; Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió 57020-720, Brazil. suzana.magna@gmail.com. |
| Abstrakt: |
In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception. In this study, we evaluated the possible mechanism of action of this alkaloid in mice, using the writhing test. The antinociceptive effect of caulerpine was not affected by intraperitoneal (i.p.) pretreatment of mice with naloxone, flumazenil, l-arginine or atropine, thus discounting the involvement of the opioid, GABAergic, l-arginine-nitric oxide and (muscarinic) cholinergic pathways, respectively. In contrast, i.p. pretreatment with yohimbine, an α2-adrenoceptor antagonist, or tropisetron, a 5-HT3 antagonist, significantly blocked caulerpine-induced antinociception. These results suggest that caulerpine exerts its antinociceptive effect in the writhing test via pathways involving α2-adrenoceptors and 5-HT3 receptors. In summary, this alkaloid could be of interest in the development of new dual-action analgesic drugs. |
