Organization, control and function of extrasynaptic NMDA receptors.

Autor:	Papouin T; Neuroscience Department, Tufts University School of Medicine, Boston, MA 02111, USA., Oliet SH; Neurocentre Magendie, Inserm U862, Bordeaux, France Université de Bordeaux, Bordeaux, France stephane.oliet@inserm.fr.
Jazyk:	angličtina
Zdroj:	Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2014 Oct 19; Vol. 369 (1654), pp. 20130601.
DOI:	10.1098/rstb.2013.0601
Abstrakt:	N-methyl D-aspartate receptors (NMDARs) exist in different forms owing to multiple combinations of subunits that can assemble into a functional receptor. In addition, they are located not only at synapses but also at extrasynaptic sites. There has been intense speculation over the past decade about whether specific NMDAR subtypes and/or locations are responsible for inducing synaptic plasticity and excitotoxicity. Here, we review the latest findings on the organization, subunit composition and endogenous control of NMDARs at extrasynaptic sites and consider their putative functions. Because astrocytes are capable of controlling NMDARs through the release of gliotransmitters, we also discuss the role of the glial environment in regulating the activity of these receptors. (© 2014 The Author(s) Published by the Royal Society. All rights reserved.)
Databáze:	MEDLINE
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