Derangements in bone mineral parameters and bone mineral density in south Indian subjects on antiepileptic medications.

Autor: Koshy G; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Varghese RT; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Naik D; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Asha HS; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Thomas N; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Seshadri MS; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Alexander M; Department of Neurological Science, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Thomas M; Department of Neurological Science, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Aaron S; Department of Neurological Science, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India., Paul TV; Department of Endocrinology, Diabetes and Metabolism, Unit-III, Christian Medical College, Vellore, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Annals of Indian Academy of Neurology [Ann Indian Acad Neurol] 2014 Jul; Vol. 17 (3), pp. 272-6.
DOI: 10.4103/0972-2327.138489
Abstrakt: Background: Although there are reports describing the association of alternations of bone and mineral metabolism in epileptic patients with long-term anticonvulsant therapy, there are only limited Indian studies which have looked at this aspect.
Objectives: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long-term anticonvulsant therapy with age- and body mass index (BMI)-matched healthy controls.
Materials and Methods: There were 55 men (on medications for more than 6 months) and age- and BMI-matched 53 controls. Drug history, dietary calcium intake (DCI), and duration of sunlight exposure were recorded. Bone mineral parameters and BMD were measured.
Results: The control group had a significantly higher daily DCI with mean ± SD of 396 ± 91 mg versus 326 ± 101 mg (P = 0.007) and more sunlight exposure of 234 ± 81 vs 167 ± 69 min (P = 0.05). BMD at the femoral neck was significantly lower in cases (0.783 ± 0.105 g/cm(2)) when compared to controls (0.819 ± 0.114 g/cm(2)). Majority of the patients (61%) had low femoral neck BMD (P = 0.04). There was no significant difference in the proportion of subjects with vitamin D deficiency (<20 ng/mL) between cases (n = 32) and controls (n = 37) (P = 0.234).
Conclusions: Vitamin D deficiency was seen in both the groups in equal proportions, highlighting the existence of a high prevalence of this problem in India. Low femoral neck BMD found in cases may stress the need for supplementing calcium and treating vitamin D deficiency in this specific group. However, the benefit of such intervention has to be studied in a larger proportion of epileptic patients.
Databáze: MEDLINE