Doppler-based flow rate sensing in microfluidic channels.

Autor: Stern L; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. liron.stern@mail.huji.ac.il., Bakal A; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. avibakal@gmail.com., Tzur M; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. mor.tzur11@gmail.com., Veinguer M; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. myview21@yahoo.com., Mazurski N; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. noam@savion.huji.ac.il., Cohen N; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. nadav_cohen@mod.gov.il., Levy U; Department of Applied Physics, The Benin School of Engineering and Computer Science, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. ulevy@mail.huji.ac.il.
Jazyk: angličtina
Zdroj: Sensors (Basel, Switzerland) [Sensors (Basel)] 2014 Sep 10; Vol. 14 (9), pp. 16799-807. Date of Electronic Publication: 2014 Sep 10.
DOI: 10.3390/s140916799
Abstrakt: We design, fabricate and experimentally demonstrate a novel generic method to detect flow rates and precise changes of flow velocity in microfluidic devices. Using our method we can measure flow rates of ~2 mm/s with a resolution of 0.08 mm/s. The operation principle is based on the Doppler shifting of light diffracted from a self-generated periodic array of bubbles within the channel and using self-heterodyne detection to analyze the diffracted light. As such, the device is appealing for variety of "lab on chip" bio-applications where a simple and accurate speed measurement is needed, e.g., for flow-cytometry and cell sorting.
Databáze: MEDLINE
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