| Autor: |
Polonio IB; Department of Pulmonology, Santa Casa School of Medical Sciences in São Paulo, São Paulo, Brazil., Acencio MM; Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil., Pazetti R; Department of Thoracic Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil., Almeida FM; Department of Thoracic Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil., Silva BS; Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil., Pereira KA; Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil., Souza R; Department of Pulmonology, School of Medicine, University of São Paulo, São Paulo, Brazil. |
| Abstrakt: |
We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. We conclude that lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation. |
