| Autor: |
Dubey P; King George Medical University Department of Surgical Oncology Lucknow India., Shrivastava R; Central Drug Research Institute Division of Toxicology Lucknow India., Tripathi C; Central Drug Research Institute Division of Toxicology Lucknow India., Jain NK; Central Drug Research Institute Division of Toxicology Lucknow India., Tewari BN; King George Medical University Department of Surgical Oncology Lucknow India., Lone MU; Central Drug Research Institute Division of Toxicology Lucknow India., Baghel KS; Central Drug Research Institute Division of Toxicology Lucknow India., Kumar V; King George Medical University Department of Surgical Oncology Lucknow India., Misra S; King George Medical University Department of Surgical Oncology Lucknow India., Bhadauria S; Central Drug Research Institute Division of Toxicology Lucknow India smraticdri@gmail.com., Bhatt ML; Dr.R M L Institute of Medical sciences Department of Radiation Oncology Lucknow India drmlbhatt@yahoo.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2014 Sep 12; Vol. 60 (3), pp. 10-5. Date of Electronic Publication: 2014 Sep 12. |
| Abstrakt: |
Tumor-associated macrophages (TAMs), represent a major subpopulation of tumor infiltrating immune cells. These alternatively activated M2-polarized macrophages are well known for their pro-tumor functions. Owing to their established role in potentiating tumor-neovasculogenesis and metastasis, TAMs have emerged as promising target for anti-cancer immunotherapy. One of the key TAMs related phenomenon that is amenable to therapeutic intervention is their phenotype switching into alternatively activated M2-polarized macrophages. Hindering macrophage polarization towards a pro-tumor M2 phenotype, or better still reprogramming the M2 like TAMs towards M1 subtype is being considered a beneficial anti-cancer strategy. Hypoxic tumor milieu has been proposed as one of the most plausible factor governing M2-polarization of macrophages. We recently demonstrated that hypoxic tumor cells imparted a pro—angiogenic M2 skewed phenotype to macrophages. Furthermore, sizeable body of data indicates for participation of cyclooxygenase-2 (COX-2) in macrophage polarization. Concordantly, inhibition of COX-2 is associated with impaired macrophage polarization. Prompted by this in the current study we decided to explore if inhibition of COX-2 activity via chemical inhibitors may prevent hypoxic cancer cell induced M2-polarization of macrophages. We observed that treatment with Flunixin meglumine, an established preferential inhibitor of COX-2 activity markedly inhibited hypoxic cancer cell induced of M2-polarization of macrophages thereby indicating for usage of COX-2 inhibition as possible anti-cancer treatment modality. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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