The role of parathyroidectomy in JAK2 mutation negative polycythemia vera.

Autor: Kulaylat AN; Department of Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA., Jung EE, Saunders BD
Jazyk: angličtina
Zdroj: International journal of hematology [Int J Hematol] 2014 Dec; Vol. 100 (6), pp. 615-8. Date of Electronic Publication: 2014 Sep 11.
DOI: 10.1007/s12185-014-1668-x
Abstrakt: The relationship between polycythemia vera (PV) and primary hyperparathyroidism is not well understood. Remission or improvement of PV following parathyroidectomy in the setting of primary hyperparathyroidism has previously been described; however, long-term outcomes are not well characterized. We describe a patient with JAK2 mutation negative PV and primary hyperparathyroidism, with a dramatic, but ultimately transient, improvement in hemoglobin following resection of a parathyroid adenoma. While screening for hyperparathyroidism may be useful in the setting of PV, indications for parathyroidectomy should be driven by symptomatology or established criteria, not the desire to affect the clinical course of PV.
Databáze: MEDLINE