Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.

Autor: Irier H; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Street RC; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Dave R; Williams College, Williamstown, MA 01267, USA., Lin L; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Cai C; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Davis TH; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Yao B; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Cheng Y; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Jin P; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: peng.jin@emory.edu.
Jazyk: angličtina
Zdroj: Genomics [Genomics] 2014 Nov; Vol. 104 (5), pp. 376-82. Date of Electronic Publication: 2014 Sep 07.
DOI: 10.1016/j.ygeno.2014.08.019
Abstrakt: Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity. To identify the role of 5hmC in gene-environment interactions, we exposed both young (6-week-old) and aged (18-month-old) mice to both an enriched environment and a standard environment. Exposure to EE significantly improves learning and memory in aged mice and reduces 5hmC abundance in mouse hippocampus. Furthermore, we mapped the genome-wide distribution of 5hmC and found that the alteration of 5hmC modification occurred mainly at gene bodies. In particular, genes involved in axon guidance are enriched among the genes with altered 5hmC modification. These results together suggest that environmental enrichment could modulate the dynamics of 5hmC in hippocampus, which could potentially contribute to improved learning and memory in aged animals.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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