Functional connectivity in preterm infants derived from EEG coherence analysis.

Autor:	Meijer EJ; Clinical Physics, Máxima Medical Center, Veldhoven, The Netherlands. Electronic address: e.meijer@mmc.nl., Hermans KH; Clinical Physics, Máxima Medical Center, Veldhoven, The Netherlands; Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands., Zwanenburg A; Biomedical Engineering, Maastricht University, Maastricht, The Netherlands., Jennekens W; Medical Physics and Technology, Maasstad Hospital, Rotterdam, The Netherlands., Niemarkt HJ; Neonatal Intensive Care Unit, Máxima Medical Center, Veldhoven, The Netherlands., Cluitmans PJ; Medical Electrical Engineering, Eindhoven University of Technology, The Netherlands., van Pul C; Clinical Physics, Máxima Medical Center, Veldhoven, The Netherlands., Wijn PF; Clinical Physics, Máxima Medical Center, Veldhoven, The Netherlands; Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands., Andriessen P; Neonatal Intensive Care Unit, Máxima Medical Center, Veldhoven, The Netherlands; Faculty of Health, Medicine and Life Science, University of Maastricht, Maastricht, The Netherlands. Electronic address: p.andriessen@mmc.nl.
Jazyk:	angličtina
Zdroj:	European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2014 Nov; Vol. 18 (6), pp. 780-9. Date of Electronic Publication: 2014 Aug 26.
DOI:	10.1016/j.ejpn.2014.08.003
Abstrakt:	Objective: To quantify the neuronal connectivity in preterm infants between homologous channels of both hemispheres. Methods: EEG coherence analysis was performed on serial EEG recordings collected from preterm infants with normal neurological follow-up. The coherence spectrum was divided in frequency bands: δnewborn(0-2 Hz), θnewborn(2-6 Hz), αnewborn(6-13 Hz), βnewborn(13-30 Hz). Coherence values were evaluated as a function of gestational age (GA) and postnatal maturation. Results: All spectra show two clear peaks in the δnewborn and θnewborn-band, corresponding to the delta and theta EEG waves observed in preterm infants. In the δnewborn-band the peak magnitude coherence decreases with GA and postnatal maturation for all channels. In the θnewborn-band, the peak magnitude coherence decreases with GA for all channels, but increases with postnatal maturation for the frontal polar channels. In the βnewborn-band a modest magnitude coherence peak was observed in the occipital channels, which decreases with GA. Conclusions: Interhemispherical connectivity develops analogously with electrocortical maturation: signal intensities at low frequencies decrease with GA and postnatal maturation, but increase at high frequencies with postnatal maturation. In addition, peak magnitude coherence is a clear trend indicator for brain maturation. Significance: Coherence analysis can aid in the clinical assessment of the functional connectivity of the infant brain with maturation. (Copyright © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect