Centromere licensing: Mis18 is required to Polo-ver.
| Autor: | Barnhart-Dailey MC; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA., Foltz DR; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA; Department of Cell Biology, University of Virginia, Charlottesville, VA 22901, USA. Electronic address: drf3q@virginia.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2014 Sep 08; Vol. 24 (17), pp. R808-10. |
| DOI: | 10.1016/j.cub.2014.07.026 |
| Abstrakt: | The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome. (Copyright © 2014 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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