| Autor: |
Zavesky BP; Department of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109-1005, United States., Babij NR, Wolfe JP |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2014 Sep 19; Vol. 16 (18), pp. 4952-5. Date of Electronic Publication: 2014 Sep 08. |
| DOI: |
10.1021/ol502471x |
| Abstrakt: |
A new method for the synthesis of 2-aminoimidazole products is described. The heterocyclic products are generated in good yields via Pd-catalyzed carboamination reactions of N-propargyl guanidines and aryl triflates. This methodology generates both a C-N and C-C bond during the annulation step and facilitates the rapid construction of 2-aminoimidazole products with different aryl groups. The utility of this methodology was demonstrated in the total synthesis of preclathridine A, preclathridine B, and dorimidazole B from a single intermediate. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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