Metabolic control and cardiovascular risk factors in type 2 diabetes mellitus patients according to diabetes duration.

Autor:	Franch-Nadal J; Primary Care Center Raval Sud, Barcelona, Spain; Barcelona Ciutat Research Support Unit - IDIAP Jordi Gol, Barcelona, Spain; josep.franch@gmail.com., Roura-Olmeda P; PCC Badía del Vallés, Barcelona, Spain;, Benito-Badorrey B; Primary Care Center Raval Sud, Barcelona, Spain;, Rodriguez-Poncelas A; PCC Anglés, Girona, Spain; Research Unit, Healthcare Institute, Girona, Spain;, Coll-de-Tuero G; PCC Anglés, Girona, Spain; Research Unit, Healthcare Institute, Girona, Spain; Translab. Departament of Medical Sciences, University of Girona, Girona, Spain and., Mata-Cases M; Barcelona Ciutat Research Support Unit - IDIAP Jordi Gol, Barcelona, Spain; PCC La Mina, Sant Adrià de Besòs, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Family practice [Fam Pract] 2015 Feb; Vol. 32 (1), pp. 27-34. Date of Electronic Publication: 2014 Sep 05.
DOI:	10.1093/fampra/cmu048
Abstrakt:	Background: Control of glycaemic levels as well as cardiovascular risk factors (CVRF) is essential to prevent the onset of complications associated with type 2 diabetes mellitus (T2DM). Aim: To describe the degree of glycaemic control and CVRF in relation to diabetes duration. Patients and Methods: Multicentre cross-sectional study in T2DM patients seen in primary care centres during 2007. Variables: Demographical and clinical characteristics, antidiabetic treatments and development of disease complications. Diabetes duration classification: 0-5, 6-10, 11-20 and >20 years. Logistic regression models were used in the analysis. Results: A total of 3130 patients; 51.5% males; mean age: 68±11.7 years; mean diabetes duration:7.0 (±5.6) years, median: 5 (interquartile range:3-9) years; mean HbA1c: 6.84 (±1.5), were analyzed. There has been a progressive decline in HbA1c levels (HbA1c > 7% in 25.8% of patients during the first 5 years and 51.8% after 20 years). Blood pressure values remained relatively stable throughout disease duration. The mean value of low density lipoprotein (LDL) experienced a slight decline with the progression of the disease, but due to the significant increase of cardiovascular disease (CVD) after 20 years of duration, less patients reached the recommended target (LDL < 100mg/dl) in secondary prevention. Logistic regression model controlling for age, sex and CVD showed that diabetes duration was related to glycaemic control (odds ratio: 1.066, 95% confidence interval: 1.050-1.082 per year) but not to blood pressure or LDL control. Conclusions: The degree of glycaemic control and the risk factors in relation to the duration of T2DM followed different patterns. Diabetes duration was associated with a poorer glycaemic control but in general had a limited role in blood pressure control or lipid profile. (© The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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