Age at hormonal onset of puberty based on luteinizing hormone, inhibin B, and body composition in preadolescent U.S. girls.

Autor:	Addo OY; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia., Miller BS; Division of Pediatric Endocrinology, University of Minnesota Amplatz Children's Hospital and Medical School, Minneapolis, Minnesota., Lee PA; Department of Pediatrics, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, Pennsylvania., Hediger ML; Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Himes JH; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota.
Jazyk:	angličtina
Zdroj:	Pediatric research [Pediatr Res] 2014 Dec; Vol. 76 (6), pp. 564-70. Date of Electronic Publication: 2014 Sep 05.
DOI:	10.1038/pr.2014.131
Abstrakt:	Background: Hormonal indicators could be useful for detecting early pubertal onset, but there is little research on how they are related to puberty in U.S. girls. We determined median age at hormonal onset of puberty based on luteinizing hormone (LH) and inhibin B (InB) and explored the extent to which body composition moderates this timing process. Methods: We analyzed anthropometric and hormone data of 698 US peri-pubertal girls ages 6-11.99 y who had participated in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Results: Median age of hormonal onset of puberty was 10.43 y by LH and 10.08 y by InB cut-offs (1.04 mIU/ml for LH and 17.89 pg/ml for InB). Postnatal weight gain modulated onset, making it earlier by 10-11 mo among the highest (greater than +1 SD) relative to normal weight gainers. Onset occurred first in non-Hispanic black (NHB) girls, 10.08 y (95% confidence interval (CI): 10.07-10.09), followed by Mexican-American (MXAM) at 10.64 y (95% CI: 10.63-10.65), and at 10.66 y (95% CI: 10.66-10.67) for non-Hispanic white (NHW) girls using LH. With InB, onset occurred first in MXAM girls at 9.9 y, and at 10.3 y and 10.4 y for their NHB and NHW peers, respectively. Conclusion: Preadolescent weight gain lowers the age at hormonal onset as defined by LH concentrations. Preventing obesity in childhood may also avert the earlier initiation of the maturation process even at the hormonal level.
Databáze:	MEDLINE
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