Experimental study of radiomodifying properties of N-stearoilethanolamine under a combined impact of ionizing radiation and stress.
| Autor: | Derevyanko LP, Shelkovskiy MV, Tal'ko VV, Atamaniuk NP, Frolova NO, Kosyakova GV, Mehed OF, Gula NM, Chumak AA |
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| Jazyk: | English; Ukrainian |
| Zdroj: | Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2013 (18), pp. 322-9. |
| Abstrakt: | Objective: to investigate the radiomodifying properties of N-stearoilethanolamine (NSE) in experiment under different conditions of a combined impact of ionizing radiation and stress. Methods: biochemical, statistical. Results: The radiomodifying properties of N-stearoilethanolamine were revealed under different conditions of a combined impact of ionizing radiation and stress according to the indices of plasma concentrations of TBA-active products, nitrite-anions and catalase activity. Conclusions: The radioprotective properties of NSE at a dose of 10.0 mg/kg before and after a single total 6.0 Gy irradiation of animals. The radioprotective properties of NSE are identified at a dose of 10.0 mg/kg of animal bodyweight before and after stress. The radiosensitizing properties of NSE occur upon the drug administration in a dose of 10.0 mg/kg before the combined impact of 6.0 Gy ionizing radiation and stress. (Derevjanko L. P., Shelkovskyj M. V., Talko V. V., Atamanjuk N. P., Frolova N. O., Kosjakova G. V., Meged O. F., Gula N. M., Chumak A. A., 2013.) |
| Databáze: | MEDLINE |
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