| Autor: |
Ulrich CM; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany ; Fred Hutchinson Cancer Research Center , Seattle, WA , USA., Toriola AT; Division of Public Health Sciences, Department of Surgery , Washington University School of Medicine and Siteman Cancer Center , St Louis, MO , USA., Siegel EM; H. LeeMoffitt Cancer Center , Tampa, FL , USA., Brenner H; Division of Clinical Epidemiology and Aging Research , German Cancer Research Center (DKFZ) , Heidelberg , Germany., Chang-Claude J; Department of Cancer Epidemiology , German Cancer Research Center (DKFZ) , Heidelberg , Germany., Abbenhardt C; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany., Kotzmann J; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany., Song X; Fred Hutchinson Cancer Research Center , Seattle, WA , USA., Owen RW; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany., Hoffmeister M; Division of Clinical Epidemiology and Aging Research , German Cancer Research Center (DKFZ) , Heidelberg , Germany., Becher H; University of Heidelberg , Heidelberg , Germany., Shibata D; H. LeeMoffitt Cancer Center , Tampa, FL , USA., Vickers K; Fred Hutchinson Cancer Research Center , Seattle, WA , USA., Rush SK; Fred Hutchinson Cancer Research Center , Seattle, WA , USA., Makar K; Fred Hutchinson Cancer Research Center , Seattle, WA , USA., Würtele G; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany., Haubner R; Division of Preventive Oncology , National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ) , Heidelberg , Germany., Sellers TA; H. LeeMoffitt Cancer Center , Tampa, FL , USA., Grady W; Fred Hutchinson Cancer Research Center , Seattle, WA , USA. |
| Abstrakt: |
Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls. Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrations differed by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrations were higher in Heidelberg (31·7 ng/ml; range 11·0-83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0-80·0 ng/ml) and Tampa (21·1 ng/ml; range 4·6-51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelberg were lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25(OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidance behaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater than between-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed may be due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosis to discern geographical differences in a broad range of exposures. |
