A mononuclear manganese(II) complex demonstrates a strategy to simultaneously image and treat oxidative stress.
| Autor: | Yu M; Department of Chemistry and Biochemistry, ‡Magnetic Resonance Imaging Research Center, and §Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University , Auburn, Alabama 36849, United States., Ambrose SL, Whaley ZL, Fan S, Gorden JD, Beyers RJ, Schwartz DD, Goldsmith CR |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Chemical Society [J Am Chem Soc] 2014 Sep 17; Vol. 136 (37), pp. 12836-9. Date of Electronic Publication: 2014 Sep 04. |
| DOI: | 10.1021/ja507034d |
| Abstrakt: | A manganese(II) complex with a ligand containing an oxidizable quinol group serves as a turn-on sensor for H2O2. Upon oxidation, the relaxivity of the complex in buffered water increases by 0.8 mM(-1) s(-1), providing a signal that can be detected and quantified by magnetic resonance imaging. The complex also serves as a potent antioxidant, suggesting that this and related complexes have the potential to concurrently visualize and alleviate oxidative stress. |
| Databáze: | MEDLINE |
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