Parvovirus associated fulminant hepatic failure and aplastic anemia treated successfully with liver and bone marrow transplantation. A report of two cases.

Autor: Bathla L; Methodist Specialty and Transplant Hospital, San Antonio, TX., Grant WJ, Mercer DF, Vargas LM, Gebhart CL, Langnas AN
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2014 Nov; Vol. 14 (11), pp. 2645-50. Date of Electronic Publication: 2014 Sep 01.
DOI: 10.1111/ajt.12857
Abstrakt: Aplastic anemia (AA) has been observed in nearly a third of patients undergoing liver transplantation (LT) for non-A-E fulminant hepatic failure (FHF). Few of these patients have been successfully managed with sequential LT and bone marrow transplantation (BMT). No causative agent has been identified for the FHF or AA in these reported cases. At our center, two patients, aged 15 years and 7 years, respectively, underwent sequential living-related LT and living-unrelated BMT. These patients are 10/9 years and 5/4 years post-LT/BMT. Human parvovirus B19 (HPV-B19) was established as the causative agent for FHF in both these patients by polymerase chain reaction. This report presents the first two cases associating HPV-B19 with FHF and AA who underwent sequential LT and BMT with excellent outcomes.
(© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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