Role of microglia in regulation of ethanol neurotoxic action.
| Autor: | Chastain LG; Endocrinology Program, Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA., Sarkar DK; Endocrinology Program, Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA. Electronic address: sarkar@aesop.rutgers.edu. |
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| Jazyk: | angličtina |
| Zdroj: | International review of neurobiology [Int Rev Neurobiol] 2014; Vol. 118, pp. 81-103. |
| DOI: | 10.1016/B978-0-12-801284-0.00004-X |
| Abstrakt: | Exposure to alcohol, during development or adulthood, may result in damage to the nervous system, which underlies neurological and cognitive disruptions observed in patients with alcohol-related disorders, including fetal alcohol spectrum disorders (FASDs) and alcohol-use disorders (AUDs). Both clinical and preclinical evidence suggest microglia, the immune cells of the central nervous system, play a key role in modulating alcohol-induced neurotoxicity. Particularly, microglia are implicated in alcohol-induced neuroinflammation and in alcohol-induced increases in oxidative stress, which can lead to neuronal apoptosis. Recent studies also suggest a regenerative role for microglia in reestablishing homeostasis after alcohol exposure. These studies are summarized and reviewed in this chapter with emphasis on relevance to FASD and AUD. (© 2014 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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