A test of double interspecific introgression of nucleoporin genes in Drosophila.

Autor:	Sawamura K; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572 sawamura@biol.tsukuba.ac.jp., Maehara K; Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8572., Keira Y; Department of Biology, Chiba University, Chiba, Chiba 263-8522., Ishikawa HO; Department of Biology, Chiba University, Chiba, Chiba 263-8522., Sasamura T; Department of Biological Sciences, Osaka University, Toyonaka, Osaka, Japan 560-0043., Yamakawa T; Department of Biological Sciences, Osaka University, Toyonaka, Osaka, Japan 560-0043., Matsuno K; Department of Biological Sciences, Osaka University, Toyonaka, Osaka, Japan 560-0043.
Jazyk:	angličtina
Zdroj:	G3 (Bethesda, Md.) [G3 (Bethesda)] 2014 Aug 28; Vol. 4 (11), pp. 2101-6. Date of Electronic Publication: 2014 Aug 28.
DOI:	10.1534/g3.114.014027
Abstrakt:	In interspecific hybrids between Drosophila melanogaster and Drosophila simulans, the D. simulans nucleoporin-encoding Nup96(sim) and Nup160(sim) can cause recessive lethality if the hybrid does not also inherit the D. simulans X chromosome. In addition, Nup160(sim) leads to recessive female sterility in the D. melanogaster genetic background. Here, we conducted carefully controlled crosses to better understandthe relationship between Nup96(sim) and Nup160(sim). Nup96(sim) did not lead to female sterility in the D. melanogaster genetic background, and double introgression of Nup96(sim) and Nup160(sim) did not generally lead to lethality when one was heterozygous and the other homozygous (hemizygous). It appears that introgression of additional autosomal D. simulans genes is necessary to cause lethality and that the effect of the introgression is dominant to D. melanogaster alleles. Interestingly, the genetic background affected dominance of Nup96(sim), and double introgression carrying homozygous Nup96(sim) and hemizygous Nup160(sim) resulted in lethality. Thus, Nup96(sim) and Nup160(sim) seem to be two components of the same incompatibility. (Copyright © 2014 Sawamura et al.)
Databáze:	MEDLINE
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