Linoleic and docosahexaenoic acids in human milk have opposite relationships with cognitive test performance in a sample of 28 countries.

Autor: Lassek WD; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 Desoto Street, Pittsburgh, PA 15213, United States. Electronic address: will.lassek@gmail.com., Gaulin SJ; Department of Anthropology, University of California at Santa Barbara, Santa Barbara, CA 93106-3210, United States.
Jazyk: angličtina
Zdroj: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2014 Nov; Vol. 91 (5), pp. 195-201. Date of Electronic Publication: 2014 Aug 08.
DOI: 10.1016/j.plefa.2014.07.017
Abstrakt: Polyunsaturated fatty acids play critical roles in brain development and function, and their levels in human breast milk closely reflect the long-term diet. The fatty acid contents of human milk samples from 28 countries were used to predict averaged 2009 and 2012 test scores in mathematics, reading, and science from the Program for International Student Assessment. All test scores were positively related to milk docosahexaenoic acid (r=0.48 to 0.55), and negatively related to linoleic acid (r=-0.28 to -0.56). Together, these two human milk fatty acids explained 46% to 48% of the variance in scores, with no improvement in predictive power when socioeconomic variables were added to the regression. The (log) ratio of linoleic to arachidonic acid was negatively related to scores (r=-0.45 to -0.48). Statistical effects were similar for the two sexes. In a separate US sample, estimated dietary linoleic was negatively related to the levels of all long-chain n-3 and n-6 plasma fatty acids. High levels of dietary linoleic may impair cognition by decreasing both docosahexaenoic and arachidonic acids in the brain.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: