Unusual sites of relapse in pre-B acute lymphoblastic leukemia.

Autor: Jain R; Pediatric Hematology Oncology Unit, Department of Pediatrics, Advanced Pediatric Centre Departments of †Ophthalmology ‡Cytology & Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Trehan A, Singh R, Srinivasan R, Dogra M, Bansal D, Marwaha RK
Jazyk: angličtina
Zdroj: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2014 Nov; Vol. 36 (8), pp. e506-8.
DOI: 10.1097/MPH.0000000000000240
Abstrakt: Relapses of acute lymphoblastic leukemia (ALL) in unusual sites can be challenging to diagnose. We present unusual relapses occurring in children with ALL treated in a single institution over a 22-year period. Of 172 relapses, 9 (5.2%) were at unusual sites (nonmarrow, testes, central nervous system). The most common site of relapse was ocular (66%). The median symptom-to-diagnosis interval was 20 days. Two of 9 children attained second remission. A possibility of relapse should be considered when evaluating unusual symptoms in a child with underlying ALL.
Databáze: MEDLINE