| Autor: |
Lee B; College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon, South Korea. syseo@gachon.ac.kr., Basavarajappa HD, Sulaiman RS, Fei X, Seo SY, Corson TW |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2014 Oct 21; Vol. 12 (39), pp. 7673-7. Date of Electronic Publication: 2014 Aug 28. |
| DOI: |
10.1039/c4ob01604a |
| Abstrakt: |
An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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