Supporting patient screening to identify suitable clinical trials.
| Autor: | Bucur A; Philips Research Europe, The Netherlands., Van Leeuwen J; Philips Research Europe, The Netherlands., Chen NZ; Philips Research Europe, The Netherlands., Claerhout B; Custodix NV, Belgium., De Schepper K; Custodix NV, Belgium., Perez-Rey D; Grupo de Informática Biomédica, Universidad Politécnica de Madrid, Spain., Alonso-Calvo R; Grupo de Informática Biomédica, Universidad Politécnica de Madrid, Spain., Pugliano L; The Breast International Group, Belgium., Saini K; The Breast International Group, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Studies in health technology and informatics [Stud Health Technol Inform] 2014; Vol. 205, pp. 823-7. |
| Abstrakt: | To support the efficient execution of post-genomic multi-centric clinical trials in breast cancer we propose a solution that streamlines the assessment of the eligibility of patients for available trials. The assessment of the eligibility of a patient for a trial requires evaluating whether each eligibility criterion is satisfied and is often a time consuming and manual task. The main focus in the literature has been on proposing different methods for modelling and formalizing the eligibility criteria. However the current adoption of these approaches in clinical care is limited. Less effort has been dedicated to the automatic matching of criteria to the patient data managed in clinical care. We address both aspects and propose a scalable, efficient and pragmatic patient screening solution enabling automatic evaluation of eligibility of patients for a relevant set of trials. This covers the flexible formalization of criteria and of other relevant trial metadata and the efficient management of these representations. |
| Databáze: | MEDLINE |
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