| Autor: |
Hedner U; Novo Research Institute, Bagsvaerd, Denmark., Bjoern S, Bernvil SS, Tengborn L, Stigendahl L |
| Jazyk: |
angličtina |
| Zdroj: |
Haemostasis [Haemostasis] 1989; Vol. 19 (6), pp. 335-43. |
| DOI: |
10.1159/000216080 |
| Abstrakt: |
FVIIa purified from human plasma and spontaneously activated during the purification procedure was given to 4 patients with hemophilia A and inhibitors against FVIII:C in association with joint bleeds. A dose of 9-20 micrograms/kg b.w. (700-1,000 U/kg b.w.) seemed to be hemostatically active in moderate to severe joint bleeds. Plasma levels of FVII of 5-7 U/ml were achieved and recoveries varied between 17 and 66%. The lower recovery rates of 17-39% were all found in 1 of the patients. No immediate side effects were seen. Neither were any signs of a systemic activation of the coagulation system observed. It is concluded that highly purified FVIIa may be useful in the treatment of hemophilia A patients with inhibitors against FVIII:C. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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