Tight junctions and the regulation of gene expression.

Autor: González-Mariscal L; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico. Electronic address: lorenza@fisio.cinvestav.mx., Domínguez-Calderón A; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico., Raya-Sandino A; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico., Ortega-Olvera JM; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico., Vargas-Sierra O; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico., Martínez-Revollar G; Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, México, D.F., Mexico.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2014 Dec; Vol. 36, pp. 213-23. Date of Electronic Publication: 2014 Aug 23.
DOI: 10.1016/j.semcdb.2014.08.009
Abstrakt: Tight junctions (TJ) regulate the paracellular passage of ions and molecules through the paracellular pathway and maintain plasma membrane polarity in epithelial and endothelial cells. Apart from these canonical functions, several proteins of the TJ have been found in recent years to regulate gene expression. This function is found in proteins that shuttle between the nucleus and TJs, and in integral TJ proteins. In this review, we will describe these proteins and their known mechanisms of gene regulation.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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