Adaptive immune responses at mucosal surfaces of teleost fish.

Autor: Rombout JH; Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway; Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands., Yang G; Cell Biology and Immunology Group, Wageningen University, Wageningen, The Netherlands; Shandong Provincial Key Laboratory of Animal Resistance Biology, School of Life Sciences, Shandong Normal University, Jinan 250014, China., Kiron V; Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodø, Norway. Electronic address: kvi@uin.no.
Jazyk: angličtina
Zdroj: Fish & shellfish immunology [Fish Shellfish Immunol] 2014 Oct; Vol. 40 (2), pp. 634-43. Date of Electronic Publication: 2014 Aug 21.
DOI: 10.1016/j.fsi.2014.08.020
Abstrakt: This review describes the extant knowledge on the teleostean mucosal adaptive immune mechanisms, which is relevant for the development of oral or mucosal vaccines. In the last decade, a number of studies have shed light on the presence of new key components of mucosal immunity: a distinct immunoglobulin class (IgT or IgZ) and the polymeric Ig receptor (pIgR). In addition, intestinal T cells and their putative functions, antigen uptake mechanisms at mucosal surfaces and new mucosal vaccination strategies have been reported. New information on pIgR of Atlantic cod and common carp and comparison of natural and specific cell-mediated cytotoxicity in the gut of common carp and European seabass, is also included in this review. Based on the known facts about intestinal immunology and mucosal vaccination, suggestions are made for the advancement of fish vaccines.
(Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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