Antihistamine use in children.
| Autor: | Fitzsimons R; Children's Allergy Service, Guy's and St. Thomas' NHS Foundation Trust, London, UK Department of Asthma, Allergy and Respiratory Science, King's College London, London, UK., van der Poel LA; Children's Allergy Service, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Thornhill W; Evelina Children's Pharmacy, Guy's and St. Thomas' NHS Foundation Trust, London, UK., du Toit G; Children's Allergy Service, Guy's and St. Thomas' NHS Foundation Trust, London, UK Department of Asthma, Allergy and Respiratory Science, King's College London, London, UK., Shah N; Department of Gastroenterology, Great Ormond Street Hospital, London, UK TARGID, Catholic University of Leuven, Leuven, The Netherlands., Brough HA; Children's Allergy Service, Guy's and St. Thomas' NHS Foundation Trust, London, UK Department of Asthma, Allergy and Respiratory Science, King's College London, London, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Archives of disease in childhood. Education and practice edition [Arch Dis Child Educ Pract Ed] 2015 Jun; Vol. 100 (3), pp. 122-31. Date of Electronic Publication: 2014 Aug 21. |
| DOI: | 10.1136/archdischild-2013-304446 |
| Abstrakt: | This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistamines is explored for the relief of histamine-mediated symptoms in a variety of allergic conditions including: non-anaphylactic allergic reactions, atopic eczema (AE), allergic rhinitis (AR) and conjunctivitis, chronic spontaneous urticaria (CSU) and whether they have a role in the management of intermittent and chronic cough, anaphylaxis, food protein-induced gastrointestinal allergy and asthma prevention. Second-generation H(1)-antihistamines are preferable to first-generation H(1)-antihistamines in the management of non-anaphylactic allergic reactions, AR, AE and CSU due to: their better safety profile, including minimal cognitive and antimuscarinic side effects and a longer duration of action. We offer some guidance as to the choices of H(1)-antihistamines available currently and their use in specific clinical settings. H(1)-antihistamine class, availability, licensing, age and dosing administration, recommended indications in allergic conditions and modalities of delivery for the 12 more commonly used H(1)-antihistamines in children are also tabulated. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.) |
| Databáze: | MEDLINE |
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