Nasal aerodynamics protects brain and lung from inhaled dust in subterranean diggers, Ellobius talpinus.

Autor: Moshkin MP; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia Department of Physiology, Novosibirsk State University, Novosibirsk 630090, Russia Department of Zoology and Animal Ecology, Tomsk State University, Tomsk 634050, Russia mmp@bionet.nsc.ru., Petrovski DV; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Akulov AE; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Romashchenko AV; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia Design Technological Institute of Digital Techniques, Siberian Branch of RAS, Novosibirsk 630090, Russia., Gerlinskaya LA; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Ganimedov VL; Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Muchnaya MI; Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Sadovsky AS; Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch of RAS, Novosibirsk 630090, Russia., Koptyug IV; International Tomographic Center, Siberian Branch of RAS, Novosibirsk 630090, Russia., Savelov AA; International Tomographic Center, Siberian Branch of RAS, Novosibirsk 630090, Russia., Troitsky SY; Boreskov Institute of Catalysis, Siberian Branch of RAS, Novosibirsk 630090, Russia., Moshkn YM; Department of Biochemistry, Erasmus Medical Center, Dr. Molewaterplein 50, Rotterdam 3015GE, The Netherlands., Bukhtiyarov VI; Boreskov Institute of Catalysis, Siberian Branch of RAS, Novosibirsk 630090, Russia., Kolchanov NA; Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk 630090, Russia Department of Physiology, Novosibirsk State University, Novosibirsk 630090, Russia., Sagdeev RZ; International Tomographic Center, Siberian Branch of RAS, Novosibirsk 630090, Russia., Fomin VM; Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch of RAS, Novosibirsk 630090, Russia.
Jazyk: angličtina
Zdroj: Proceedings. Biological sciences [Proc Biol Sci] 2014 Oct 07; Vol. 281 (1792).
DOI: 10.1098/rspb.2014.0919
Abstrakt: Inhalation of air-dispersed sub-micrometre and nano-sized particles presents a risk factor for animal and human health. Here, we show that nasal aerodynamics plays a pivotal role in the protection of the subterranean mole vole Ellobius talpinus from an increased exposure to nano-aerosols. Quantitative simulation of particle flow has shown that their deposition on the total surface of the nasal cavity is higher in the mole vole than in a terrestrial rodent Mus musculus (mouse), but lower on the olfactory epithelium. In agreement with simulation results, we found a reduced accumulation of manganese in olfactory bulbs of mole voles in comparison with mice after the inhalation of nano-sized MnCl2 aerosols. We ruled out the possibility that this reduction is owing to a lower transportation from epithelium to brain in the mole vole as intranasal instillations of MnCl2 solution and hydrated nanoparticles of manganese oxide MnO · (H2O)x revealed similar uptake rates for both species. Together, we conclude that nasal geometry contributes to the protection of brain and lung from accumulation of air-dispersed particles in mole voles.
(© 2014 The Author(s) Published by the Royal Society. All rights reserved.)
Databáze: MEDLINE