| Autor: |
Connolly T; Bristol-Myers Squibb Research & Development , Department of Discovery Chemistry, 5 Research Parkway, Wallingford, Connecticut 06492, United States., Wang Z, Walker MA, McDonald IM, Peese KM |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2014 Sep 05; Vol. 16 (17), pp. 4444-7. Date of Electronic Publication: 2014 Aug 20. |
| DOI: |
10.1021/ol5019739 |
| Abstrakt: |
An operationally simple chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and can be performed in the presence of aryl halides and benzyl groups, a notable weakness of Pd-catalyzed hydrogenations. Scope and mechanistic considerations are presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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