Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract.

Autor: Martinez-Lopez A; Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain; Department of Pathology, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain., Montes-Moreno S, Ramos R, Afonso-Martin JL, Mazorra F, Gonzalez de Villambrosia S, Batlle A, Grogan TM, Piris MA
Jazyk: angličtina
Zdroj: Histopathology [Histopathology] 2014 Dec; Vol. 65 (6), pp. 805-13. Date of Electronic Publication: 2014 Oct 30.
DOI: 10.1111/his.12511
Abstrakt: Aims: Immunoglobulin light-chain expression is used routinely as an indirect marker of clonality for recognizing B cell lymphoproliferative disorders.
Methods and Results: Here we describe four floral follicular hyperplasia cases in the gastrointestinal tract (appendix and rectum) of children (4 to 6 years). Immunohistochemical studies revealed lambda light-chain restriction that was associated with polyclonal IgH pattern. Clinical features and follow-up of the patients did not reveal any other systemic symptoms, laboratory abnormalities or organ alterations.
Conclusions: Recognition of this phenomenon is useful in the diagnosis of nodular lymphoid hyperplasia of the gastrointestinal tract, for avoiding overdiagnosis of lymphoid malignancies, and raises concerns that the identification of light-chain restriction is not necessarily a marker of monoclonality.
(© 2014 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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