Effect of a late evening meal on nitrogen balance in patients with cirrhosis of the liver.
| Autor: | Swart GR; Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands., Zillikens MC, van Vuure JK, van den Berg JW |
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| Jazyk: | angličtina |
| Zdroj: | BMJ (Clinical research ed.) [BMJ] 1989 Nov 11; Vol. 299 (6709), pp. 1202-3. |
| DOI: | 10.1136/bmj.299.6709.1202 |
| Abstrakt: | Objective: To assess whether a late evening meal would improve nitrogen balance in patients with cirrhosis of the liver. Design: Randomised crossover study of meal schedules comparing three meals a day with four or six meals a day, the four and six meal schedules both including a late evening meal (2300). Setting: Metabolic ward. Patients: Seven men and two women aged 34-66 with cirrhosis of the liver (Child's grade B). Interventions: Patients spent two seven day periods in the ward. For five days of each period they received, in random order, isonitrogenous isocaloric diets supplied in three meals a day and in four or six meals a day. Main Outcome Measure: Nitrogen balance, calculated as the difference between dietary intake and the total of urinary, faecal, and integumental nitrogen loss. Results: Faecal nitrogen loss was no different between three meals a day and four or six meals a day. On both four and six meals a day, however, patients had nitrogen balances that were more positive (or less negative) than on three meals a day (1.26 (SD 2.1) g/24 h v 0.26 (2.2) g/24 h, p less than 0.01). Six meals a day did not produce significantly better improvements in nitrogen balance than four meals a day. Conclusions: A late evening meal seemed to improve the efficiency of nitrogen metabolism, but longer term studies are needed to assess whether this leads to a better nutritional state. |
| Databáze: | MEDLINE |
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