A new method for measuring the speed of sound in rat liver ex vivo using an ultrasound system: correlation of sound speed with fat deposition.

Autor:	Kumagai H; Department of Pediatrics, Jichi Medical University, Tochigi, Japan. Electronic address: h-kumagai@jichi.ac.jp., Yokoyama K; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Katsuyama K; Imaging Technology Center, R&D Management Headquarters, Fujifilm Corporation, Tokyo, Japan., Hara S; Imaging Technology Center, R&D Management Headquarters, Fujifilm Corporation, Tokyo, Japan., Yamamoto H; Imaging Technology Center, R&D Management Headquarters, Fujifilm Corporation, Tokyo, Japan., Yamagata T; Department of Pediatrics, Jichi Medical University, Tochigi, Japan., Taniguchi N; Department of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan., Hirota N; Hirota Surgical Pathology Institute, Tochigi, Japan., Itoh K; Hitachiomiya Saiseikai Hospital, Japan.
Jazyk:	angličtina
Zdroj:	Ultrasound in medicine & biology [Ultrasound Med Biol] 2014 Oct; Vol. 40 (10), pp. 2499-507. Date of Electronic Publication: 2014 Aug 15.
DOI:	10.1016/j.ultrasmedbio.2014.03.019
Abstrakt:	The speed of sound correlates well with the fat content of the liver. Therefore, non-invasive quantification of sound speed in the liver might be of diagnostic value. Here we describe a new non-invasive method that would be clinically applicable for measurement of sound speed in the liver. Sprague-Dawley rats were divided into two groups: a control group and a fatty liver group prepared by keeping the rats on a choline-deficient diet for 6 wk. The livers were subjected to pathologic and biochemical analysis; the speed of sound through the liver tissue was measured using our proposed method and a pulser-receiver as standard. Our results indicated that use of the proposed method makes it feasible to diagnose fatty liver with good accuracy on the basis of sound speed. This approach would have considerable potential for non-invasive diagnosis of fatty liver and would be a valuable adjunct to conventional liver diagnostic procedures. (Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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