Physical activity modifies the associations between genetic variants and blood pressure in European adolescents.

Autor: de Moraes AC; Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain. Electronic address: augustocesar.demoraes@usp.br., Fernández-Alvira JM; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain., Carvalho HB; Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil., Meirhaeghe A; INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France., Dallongeville J; INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France., Kafatos A; Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece., Marcos A; Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain., Molnar D; Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary., Manios Y; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece., Ruiz JR; Promoting Fitness and Health through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain., Labayen I; Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain., Widhalm K; Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria., Breidenassel C; Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Gonzalez-Gróss M; Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain., Moreno LA; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2014 Nov; Vol. 165 (5), pp. 1046-9.e1-2. Date of Electronic Publication: 2014 Aug 14.
DOI: 10.1016/j.jpeds.2014.07.007
Abstrakt: We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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