Free-radical scavenging properties and antioxidant activities of botryosphaeran and some other β-D-glucans.

Autor: Giese EC; Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1. Electronic address: egiese@cetem.gov.br., Gascon J; Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1., Anzelmo G; Istituto di Chimica Biomolecolare,Consiglio Nazionale delle Ricerche, via Campi Flegrei 34, 80078 Pozzuoli (Napoli), Italy., Barbosa AM; Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1; Departamento de Química, CCE-Universidade Estadual de Londrina, CEP: 86051-990, Londrina-PR, Brazil., da Cunha MA; Departamento de Química,Universidade Federal do Paraná, Pato Branco-PR, Brazil., Dekker RF; Biorefining Research Institute, Lakehead University, Thunder Bay, Ontario, Canada P7B 5E1. Electronic address: xylanase@gmail.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2015 Jan; Vol. 72, pp. 125-30. Date of Electronic Publication: 2014 Aug 12.
DOI: 10.1016/j.ijbiomac.2014.07.046
Abstrakt: β-D-Glucans are known to present antitumor, anticancer, and anti-inflammatory activities that are influenced by their own antioxidant capacity. The antioxidant activity of botryosphaeran, an exopolysaccharide of the (1 → 3;1 → 6)-β-D-glucan type produced by the Botryosphaeria rhodina MAMB-05 was evaluated and compared to some other β-D-glucans (lasiodiplodan an exocellular (1 → 6)-β-D-glucan from Lasiodiplodia theobromae, laminarin and curdlan), and oligosaccharides, disaccharides, and monosaccharides in a study of scavenging activities of free radicals in-vitro. Botryosphaeran displayed high total antioxidant activity (80%) as well as good scavenging activity against hydroxyl radical (90.6%), superoxide anion (37%), hydrogen peroxide (38%), and nitric oxide radical (90%). No reducing power, metal-chelating capacity or inhibition of lipid peroxidation was observed for these β-D-glucans. The results demonstrated that botryosphaeran exhibited effective antioxidant activity as supported by many different assays, suggesting that this β-D-glucan may serve as a source of a new bioactive compound with effective antioxidant activity.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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