Combinatorial gene therapy accelerates bone regeneration: non-viral dual delivery of VEGF and BMP2 in a collagen-nanohydroxyapatite scaffold.

Autor: Curtin CM; Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland; Advanced Materials and BioEngineering Research (AMBER) Centre Royal College of Surgeons in Ireland & Trinity College Dublin, Dublin, Ireland., Tierney EG, McSorley K, Cryan SA, Duffy GP, O'Brien FJ
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2015 Jan 28; Vol. 4 (2), pp. 223-7. Date of Electronic Publication: 2014 Aug 13.
DOI: 10.1002/adhm.201400397
Abstrakt: Vascularization and bone repair are accelerated by a series of gene-activated scaffolds delivering both an angiogenic and an osteogenic gene. Stem cell-mediated osteogenesis in vitro, in addition to increased vascularization and bone repair by host cells in vivo, is enhanced using all systems while the use of the nanohydroxyapatite vector to deliver both genes markedly enhances bone healing.
(© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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