Adaptation in tunably rugged fitness landscapes: the rough Mount Fuji model.

Autor:	Neidhart J; Institut für Theoretische Physik, Universität zu Köln, D-50937 Köln, Germany., Szendro IG; Institut für Theoretische Physik, Universität zu Köln, D-50937 Köln, Germany., Krug J; Institut für Theoretische Physik, Universität zu Köln, D-50937 Köln, Germany krug@thp.uni-koeln.de.
Jazyk:	angličtina
Zdroj:	Genetics [Genetics] 2014 Oct; Vol. 198 (2), pp. 699-721. Date of Electronic Publication: 2014 Aug 13.
DOI:	10.1534/genetics.114.167668
Abstrakt:	Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of empirical evidence shows that real fitness landscapes, while possessing a considerable amount of ruggedness, are smoother than predicted by the MLM. In the present article we propose and analyze a simple fitness landscape model with tunable ruggedness based on the rough Mount Fuji (RMF) model originally introduced by Aita et al. in the context of protein evolution. We provide a comprehensive collection of results pertaining to the topographical structure of RMF landscapes, including explicit formulas for the expected number of local fitness maxima, the location of the global peak, and the fitness correlation function. The statistics of single and multiple adaptive steps on the RMF landscape are explored mainly through simulations, and the results are compared to the known behavior in the MLM model. Finally, we show that the RMF model can explain the large number of second-step mutations observed on a highly fit first-step background in a recent evolution experiment with a microvirid bacteriophage. (Copyright © 2014 by the Genetics Society of America.)
Databáze:	MEDLINE
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