Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys.

Autor: Lam T; Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Quintiles, Cambridge, MA, USA., Williams PL; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA., Lee MM; Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA., Korrick SA; Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Birnbaum LS; National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA., Burns JS; Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA., Sergeyev O; Samara State Medical University, Department of Physical Education and Health, Samara, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia., Revich B; Institute for Forecasting, Russian Academy of Sciences, Moscow, Russia., Altshul LM; Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Environmental Health and Engineering, Inc., Needham, MA, USA., Patterson DG Jr; EnviroSolutions Consulting, Inc., Auburn, GA, USA; Axys Analytical Solutions, Sidney, BC, Canada; Exponent, Inc., Maynard, MA, USA., Turner WE; Centers for Disease Control and Prevention, Atlanta, GA, USA., Hauser R; Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: rhauser@hsph.harvard.edu.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2014 Dec; Vol. 73, pp. 135-42. Date of Electronic Publication: 2014 Aug 10.
DOI: 10.1016/j.envint.2014.06.020
Abstrakt: Background: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent.
Objective: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset.
Methods: In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset.
Results: In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3 mL and P2+ (but not G2+). Mean age at attaining TV>3 mL was delayed 3.6 (95% CI: -2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: -1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: -5.8, 5.6) for Q2, 4.7 months later (95% CI: -1.0, 10.3) for Q3 and 4.6 months later (95% CI: -1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p'-DDE concentrations with age of pubertal onset.
Conclusion: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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