Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving.

Autor: Moreira Gabriel EF, Tomazelli Coltro WK, Garcia CD
Jazyk: angličtina
Zdroj: Electrophoresis [Electrophoresis] 2014 Aug; Vol. 35 (16), pp. 2325-32.
DOI: 10.1002/elps.201470140
Abstrakt: This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector, while the explored engraving parameters included power, speed, frequency, resolution, line-width, and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.
(© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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