Bone mineral density after bariatric surgery. A systematic review.

Autor: Rodríguez-Carmona Y; Nutrigenetics and Nutrigenomics Laboratory, Instituto Nacional de Medicina Genómica, Periférico Sur 4809, Arenal Tepepan, Tlalpan, CP 14610 Mexico City, Mexico. Electronic address: yanrdz@gmail.com., López-Alavez FJ; Universidad Autónoma Metropolitana Unidad Xochimilco, Calzada del Hueso 1100, Villa Quietud, Coyoacán, CP 04960 Mexico City, Mexico. Electronic address: flas20@hotmail.com., González-Garay AG; Department of Research Methodology, Instituto Nacional de Pediatría, Insurgentes Sur 3700C, Insurgentes Cuicuilco, Coyoacán, CP 04530 Mexico City, Mexico. Electronic address: pegasso.100@hotmail.com., Solís-Galicia C; Instituto Nacional de Pediatría, Insurgentes Sur 3700C, Insurgentes Cuicuilco, Coyoacán, CP 04530 Mexico City, Mexico. Electronic address: solisgc@yahoo.com.mx., Meléndez G; Hospital General de México 'Dr. Eduardo Liceaga', Dr. Balmis 148 Col. Doctores, Cuauhtémoc, CP 06726 Mexico City, Mexico. Electronic address: melendez651@gmail.com., Serralde-Zúñiga AE; Clinical Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Sección XVI Tlalpan, CP 14000, Mexico City, Mexico. Electronic address: aurozabeth@yahoo.com.mx.
Jazyk: angličtina
Zdroj: International journal of surgery (London, England) [Int J Surg] 2014; Vol. 12 (9), pp. 976-82. Date of Electronic Publication: 2014 Aug 08.
DOI: 10.1016/j.ijsu.2014.08.002
Abstrakt: Purpose: Bone regulation system may be affected after bariatric surgeries, but procedures impact differently to bone mineral density (BMD) and measures restraining bone loss are frequently neglected until clinical consequences become manifest. This is a systematic review aimed to elucidate whether BMD loss is comparable after different bariatric surgeries.
Materials and Methods: A search of morbid obese adults, undergone to bariatric surgery, with BMD measured by dual-energy X-ray absorptiometry at baseline and after surgery studies was performed in several databases. Studies were assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and COCHRANE Risk of Bias tool. The random model was selected for meta-analysis; heterogeneity was analyzed with T(2), inconsistency (I(2) > 50%) and Chi(2) (p < 0.10). Level of evidence and strength of recommendations were summarized using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE System).
Results: Twelve studies met the selection criteria. After one year, reduction in total BMD in patients with mixed surgical procedures was significant: -0.03 g/cm(2) (CI 95% 0.00 to -0.06, p < 0.05). BMD was reduced by -0.12 g/cm(2) (CI 95% -0.10 to -0.15, p < 0.001) in the hip, -0.07 g/cm(2) (CI 95% -0.03 to -0.11, p < 0.001) in the column, and -0.03 g/cm(2) (IC 95% -0.02 to -0.04, p < 0.001) in the forearm, but not in restrictive surgeries. Studies included showed high heterogeneity and low quality of evidence.
Conclusions: Patients undergone to mixed bariatric surgery had significant higher BMD deterioration as demonstrated in this review, suggesting that more attention for preventing fractures is required.
(Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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