Dopamine transporter imaging using 99mTc-TRODAT-1 SPECT in Parkinson's disease.

Autor:	Bor-Seng-Shu E; Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Felicio AC; Departments of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil., Braga-Neto P; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil., Batista IR; Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil., Paiva WS; Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., de Andrade DC; Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Teixeira MJ; Division of Neurological Surgery, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., de Andrade LA; Department of Neurology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Barsottini OG; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil., Shih MC; Department of Neurology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Bressan RA; Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, Brazil., Ferraz HB; Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2014 Aug 11; Vol. 20, pp. 1413-8. Date of Electronic Publication: 2014 Aug 11.
DOI:	10.12659/MSM.890522
Abstrakt:	Background: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients. Material/methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age- and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using 99mTc-TRODAT-1. Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal 99mTc-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal 99mTc-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal 99mTc-TRODAT-1 binding values provided by different readers, contrary to 99mTc-TRODAT-1 binding estimates in the caudate nucleus. Conclusions: Striatal DAT imaging using 99mTc-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.
Databáze:	MEDLINE
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