| Autor: |
Zhang Y; Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States., Lu BZ, Li G, Rodriguez S, Tan J, Wei HX, Liu J, Roschangar F, Ding F, Zhao W, Qu B, Reeves D, Grinberg N, Lee H, Heckmann G, Niemeier O, Brenner M, Tsantrizos Y, Beaulieu PL, Hossain A, Yee N, Farina V, Senanayake CH |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2014 Sep 05; Vol. 16 (17), pp. 4558-61. Date of Electronic Publication: 2014 Aug 08. |
| DOI: |
10.1021/ol5021114 |
| Abstrakt: |
A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127, 1) was achieved, featuring efficient Pd-catalyzed one-pot borylation-Suzuki coupling where TFP was identified as the unique ligand effective for these transformations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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