| Autor: |
Hargreaves KR; Department of Infection, Immunity and Inflammation; University of Leicester; Leicester, UK., Kropinski AM; Laboratory for Foodborne Zoonoses; Public Health Agency of Canada; West Guelph, Ontario CA ; Department of Molecular and Cellular Biology; University of Guelph; Guelph, Ontario CA., Clokie MR; Department of Infection, Immunity and Inflammation; University of Leicester; Leicester, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Bacteriophage [Bacteriophage] 2014 Jul 08; Vol. 4, pp. e29866. Date of Electronic Publication: 2014 Jul 08 (Print Publication: 2014). |
| DOI: |
10.4161/bact.29866 |
| Abstrakt: |
Bacteriophages have an essential gene kit that enables their invasion, replication, and production. In addition to this "core" genome, they can carry "accessory" genes that dramatically impact bacterial biology, and presumably boost their own success. The content of phage genomes continue to surprise us by revealing new ways that viruses impact bacterial biology. The genome of a Clostridium difficile myovirus, phiCDHM1, contains homologs of three bacterial accessory gene regulator ( agr ) genes. The agr system is a type of quorum sensing (QS), via which the phage may modify C. difficile interactions with its environment. Although their mechanism of action is unknown, mutants in bacterial versions of these genes impact sporulation and virulence. To explore how phage QS genes may influence C. difficile biology, we examine the main categories of bacterial behavior that phages have been shown to influence and discuss how interactions via QS could influence behavior at a wider level. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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