| Autor: |
Robey RB; 1] Veterans Affairs Medical Center, White River Junction, Vermont, USA [2] Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Kidney international [Kidney Int] 2014 Aug; Vol. 86 (2), pp. 226-9. |
| DOI: |
10.1038/ki.2014.47 |
| Abstrakt: |
Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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