Comparison of healing in forelimb and hindlimb surgically induced core lesions of the equine superficial digital flexor tendon.
| Autor: | Estrada RJ; Roberto Estrada, DVM, Equine Clinic, Free Universtiy of Berlin, Oertzenweg 19b, 14163 Berlin, Germany, Phone: +49 30 838 622 99, Fax: +49 30 838 625 29, E-mail: restrada@zedat.fu-berlin.de., van Weeren PR, van de Lest CH, Boere J, Reyes M, Ionita JC, Estrada M, Lischer CJ |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary and comparative orthopaedics and traumatology : V.C.O.T [Vet Comp Orthop Traumatol] 2014; Vol. 27 (5), pp. 358-65. Date of Electronic Publication: 2014 Jul 31. |
| DOI: | 10.3415/VCOT-13-11-0136 |
| Abstrakt: | Objective: Even though equine multi-limb tendinopathy models have been reported, it is unknown if fore- and hindlimb tendon healing behave similarly. The aim of this study was to compare the healing process of surgically induced superficial digital flexor tendon (SDFT) core lesions of fore- and hindlimbs in horses. Methods: Tendon core lesions were surgically induced in the SDFT of both fore- and hindlimbs in eight horses. One randomly assigned forelimb and one randomly assigned hindlimb were injected with saline one and two weeks post-surgery. The healing process was monitored clinically and ultrasonographically. After 24 weeks, the tendons were harvested and biochemical, biomechanical and histological parameters were evaluated. Results: Twenty-four weeks post-surgery, the forelimb SDFT lesions had a significantly higher colour Doppler ultrasound vascularization score (p = 0.02) and glycosaminoglycan concentration (p = 0.04) and a significantly lower hydroxylysylpyridinoline content (p = 0.03). Clinical Relevance: Our results indicate that fore- and hindlimb SDFT surgically induced lesions exhibit significant differences in several important parameters of tendon healing 24 weeks post-surgery. These differences create significant challenges in using all four limbs and accurately interpreting the results that one might generate. Therefore these findings do not support the use of four-limb models for study of tendon injury until the reasons for these differences are much better understood. |
| Databáze: | MEDLINE |
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