Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficacies.

Autor: Yazdani Abyaneh M; Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA., Griffith RD, Falto-Aizpurua L, Nouri K
Jazyk: angličtina
Zdroj: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2014 Dec; Vol. 28 (12), pp. 1610-22. Date of Electronic Publication: 2014 Jul 30.
DOI: 10.1111/jdv.12619
Abstrakt: Vitiligo is a disorder of pigmentation affecting about 1% of the global population. It is a psychologically devastating disease with suboptimal treatment options. Narrowband ultraviolet B (NB-UVB) phototherapy has become a first-line choice for treating generalized disease. In recent years, topical calcineurin inhibitors, vitamin D analogues, antioxidant agents and other therapies have been combined with NB-UVB to improve its efficacy. This article will address what is known about the mechanisms of action of these treatments and how they may complement NB-UVB on a cellular level, as well as offer a comprehensive, evidence-based review of clinical outcomes with combination therapies.
(© 2014 European Academy of Dermatology and Venereology.)
Databáze: MEDLINE
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