Therapeutic potential of metabotropic glutamate receptor 4-positive allosteric modulator TAS-4 in rodent models of movement disorders.
Autor: | Dube A; Department of Pharmacology, Faculty of Pharmacy, SNJB's Shriman Sureshdada Jain College of Pharmacy, Jain Gurukul, Chandwad, Nashik, India., Chaudhary S; Department of Pharmacology, Faculty of Pharmacy, SNJB's Shriman Sureshdada Jain College of Pharmacy, Jain Gurukul, Chandwad, Nashik, India., Mengawade T; Department of Pharmacology, Faculty of Pharmacy, SNJB's Shriman Sureshdada Jain College of Pharmacy, Jain Gurukul, Chandwad, Nashik, India., Upasani CD; Department of Pharmacology, Faculty of Pharmacy, SNJB's Shriman Sureshdada Jain College of Pharmacy, Jain Gurukul, Chandwad, Nashik, India. Electronic address: cdupasani@rediffmail.com. |
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Jazyk: | angličtina |
Zdroj: | Journal of the neurological sciences [J Neurol Sci] 2014 Jul 10. Date of Electronic Publication: 2014 Jul 10. |
DOI: | 10.1016/j.jns.2014.07.008 |
Abstrakt: | Parkinson's disease (PD) is a very serious neurological disorder, and current methods of treatment fail to achieve long-term control. Previous studies suggest that stimulation of the metabotropic glutamate receptor 4 (mGluR4) represents a promising new approach to the symptomatic treatment of Parkinson's disease (PD). Preclinical models using both agonists and positive allosteric modulators of mGluR4 have demonstrated the potential for this receptor for the treatment of PD. In the present study, we describe the pharmacological characterization of an mGluR4 PAM, N-(2, 4-dichlorophenyl) pyridine-2-carboxamide (TAS-4), in several rodent PD models. TAS-4 is a potent and selective mGluR4 PAM of the human mGluR4 receptor (EC (Copyright © 2014. Published by Elsevier B.V.) |
Databáze: | MEDLINE |
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