Blood profile and histology in oral infections associated with diabetes.
Autor: | Cintra LT; Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil. Electronic address: lucianocintra@foa.unesp.br., da Silva Facundo AC; Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil., Prieto AK; Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil., Sumida DH; Department of Basic Science, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil., Narciso LG; Department of Clinic and Surgery and Animal Reproduction, Araçatuba Veterinary Medicine, Universidade Estadual Paulista, São Paulo, Brazil., Mogami Bomfim SR; Department of Clinic and Surgery and Animal Reproduction, Araçatuba Veterinary Medicine, Universidade Estadual Paulista, São Paulo, Brazil., Oliveira e Silva C; Department of Periodontics, Maringá Dental School, Universidade Estadual Maringá, Paraná, Brazil., Dezan-Júnior E; Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil., Gomes-Filho JE; Department of Endodontics, Araçatuba Dental School, Universidade Estadual Paulista, São Paulo, Brazil. |
---|---|
Jazyk: | angličtina |
Zdroj: | Journal of endodontics [J Endod] 2014 Aug; Vol. 40 (8), pp. 1139-44. Date of Electronic Publication: 2014 Apr 13. |
DOI: | 10.1016/j.joen.2014.01.034 |
Abstrakt: | Introduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats. (Copyright © 2014 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |