| Autor: |
Lee DH; Department of Neurology, Mount Sinai School of Medicine, New York City, New York., Mendoza M, Dvorozniak MT, Chung E, van Woert MH, Yahr MD |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neural transmission. Parkinson's disease and dementia section [J Neural Transm Park Dis Dement Sect] 1989; Vol. 1 (3), pp. 189-94. |
| DOI: |
10.1007/BF02248668 |
| Abstrakt: |
Platelet MAO activity was measured in 79 Parkinson patients (56 males and 23 females) before and during L-deprenyl therapy. Baseline platelet MAO activity was higher in females than in males with no age dependent differences. During chronic L-deprenyl therapy, MAO activity was inhibited greater than 98%. Four hours after the oral administration of the first 5 mg dose of L-deprenyl, platelet MAO activity was inhibited by 86%. By 24 hours, greater than 98% inhibition was achieved and this degree of inhibition was maintained during continuous L-deprenyl administration. Following oral administration of 10 mg L-deprenyl once a day versus 5 mg L-deprenyl twice a day, the time course of platelet MAO inhibition was similar. Five days after the termination of chronic L-deprenyl therapy, platelet MAO activity was still inhibited by 96%. MAO activity returned to normal by 2 weeks after stopping L-deprenyl. Platelet MAO activity is a useful method of monitoring bioavailability, compliance, dose-response relationship and optimal dosage schedules for L-deprenyl in Parkinson patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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