| Autor: |
Semenov DIu, Osmanov ZKh, Tonoian AG, Shapkina LG, Sokolov AV, Gorchakova MV |
| Jazyk: |
ruština |
| Zdroj: |
Vestnik khirurgii imeni I. I. Grekova [Vestn Khir Im I I Grek] 2014; Vol. 173 (1), pp. 44-6. |
| Abstrakt: |
The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers. A correlated analysis was made between obtained results of laboratory and instrumental researches and clinical course of acute pancreatitis. The decrease of MT1 receptors expression was noted on 25% in patients with acute pancreatitis. The decline of MT2 receptors expression was observed on 40% of patients with acute severe pancreatitis and in a case of acute mild pancreatitis--on 15.5%, respectively. Values of MT1 and MT2 expression were equal between healthy volunteers. The decline of MT2 expression was a prognostic unfavourable sign. Obtained results of dynamic expression assessment of MT-receptors were presented as MT2/MT1 indices. Given index didn't change during disease, because of this, the index could be used as a prognostic development marker of destructive form of acute pancreatitis at the moment of patient's admission to hospital. Mean values of MT2/MT1 were determined for the purpose of universalization of used method (1.13 +/- 0.09 for mild form and 0.81 +/- 0.09 for severe form of acute pancreatitis, respectively). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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