Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies.

Autor: Barsoum MK; Divisions of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Cohoon KP; Divisions of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA., Roger VL; Divisions of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Mehta RA; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Hodge DO; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Bailey KR; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Heit JA; Divisions of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Electronic address: heit.john@mayo.edu.
Jazyk: angličtina
Zdroj: Thrombosis research [Thromb Res] 2014 Sep; Vol. 134 (3), pp. 593-8. Date of Electronic Publication: 2014 Jul 05.
DOI: 10.1016/j.thromres.2014.06.033
Abstrakt: Introduction: Because the association of myocardial infarction (MI) and venous thromboembolism (VTE) is uncertain, we tested MI as a VTE risk factor and VTE as a predictor of MI.
Materials and Methods: Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE over the 13-year period, 1988-2000 (n=1311), one to two resident controls per VTE case (n=1511), and all residents with incident MI over the 31-year period, 1979-2010. For VTE cases and controls, we reviewed their complete medical records in the community for VTE and MI risk factors. Using conditional logistic regression we tested MI as a potential VTE risk factor, both unadjusted and after adjusting for VTE risk factors. We also followed VTE cases and controls without prior MI forward in time for incident MI through 12/31/2010, and using Cox proportional hazards modeling, tested VTE as a predictor of MI, both unadjusted and after adjusting for MI risk factors.
Results: The number (%) of MI prior to VTE among cases and controls were 75 (5.7) and 51 (3.4), respectively, and the number (%) of MI after VTE among cases and controls were 58 (4.4) and 77 (5.1), respectively. In univariate analyses, MI was significantly associated with VTE but not after adjusting for VTE risk factors. In both univariate and multivariate analyses, VTE (overall or idiopathic) was not a predictor of MI.
Conclusions: MI is not an independent risk factor for VTE, and VTE is not a predictor of MI.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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